Determination of highest dose of Ammonia without effect at Work environment through the expression of interleukin-2 cell in Rattus Novergicus

Tualeka, Abdul Rohim and Wibrata, Dwi Ananto and Ahsan, Ahsan and Rahmawati, Pudji and Russeng, Syamsiar S and Wahyu, Atjo and Sukarmin, Sukarmin (2019) Determination of highest dose of Ammonia without effect at Work environment through the expression of interleukin-2 cell in Rattus Novergicus. Journal of Medical Sciences, 7 (6). pp. 897-902. ISSN 1857-9655

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Abstract

For determining the threshold limit value firstly determined the highest dose of ammonia without effect (NOAEL). However, research on the determination of NOAEL ammonia didn't conduct in Indonesia. The aim of this study to determine the value of the highest dose of ammonia without effect (No Observed Adverse Effect Level/NOAEL) through interleukin-2 (IL-2) expression on white mice. This study used experimental laboratory research with post-test only control group design using white mice as experimental subjects. The treatment group divided into 6 groups (a group of controls and five groups with different ammonia exposure through inhalation). The trend curve of Remmele Scale Index (IRS) and histopathologic analysis could be used for determining NOAEL. The location of the highest dose of ammonia without any effect (NOAEL) of white mice was in the second group, with 0.0103 mg/kg body weight dose. Analysis of statistical tests Kruskal Wallis stated there was no significant difference in interleukin-2 expression between the control with ammonia exposed group with a significance of p (0.747) > α (0.05). There is no difference between some interleukin-2 expression in the lymphocyte cell lung white mice group exposed to ammonia and control group. The highest dose of ammonia without any effect (NOAEL) on white mice was 0.0103 mg/kg body weight.

Item Type: Article
Creators:
Creators
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NIDN
Tualeka, Abdul Rohim
UNSPECIFIED
UNSPECIFIED
Wibrata, Dwi Ananto
UNSPECIFIED
UNSPECIFIED
Ahsan, Ahsan
UNSPECIFIED
UNSPECIFIED
Rahmawati, Pudji
pudji.rahmawati@uinsby.ac.id
2025036703
Russeng, Syamsiar S
UNSPECIFIED
UNSPECIFIED
Wahyu, Atjo
UNSPECIFIED
UNSPECIFIED
Sukarmin, Sukarmin
UNSPECIFIED
UNSPECIFIED
Subjects: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111708 Health and Community Services
Divisions: Fakultas Dakwah dan Komunikasi > Pengembangan Masyarakat Islam
Depositing User: Pudji Rahmawati
Date Deposited: 10 Apr 2023 03:52
Last Modified: 10 Apr 2023 03:52
URI: http://repository.uinsa.ac.id/id/eprint/2954

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