The relationship of NT pro BNP and echocardiographic features of right ventricle disfunction with chronic obstructive pulmonary disease at Haji Adam Malik general hospital Medan

The heart and lungs are two organs that are interconnected, so that if there is a pathological condition in one of them it will interfere with the function of the other. One of the most common lung diseases we encounter is OPD.1A report from the Global Initiative for Chronic Obstructive Lung Disease (GOLD) states that in 2010 as many as 384 million people or around 11.7% of the world's population were COPD sufferers with a deathrate up to three million people each year.1Data from the Indonesian Lung Doctors Association in 2015, at least 4.5 - 5.5% of Indonesia's population is suffering from COPD, and could increase to 7.2% in rural areas.2 Chronic inflammation that occurs in COPD does not only cause disturbances in the respiratory system, but also has a significant systemic impact as a sign that there is a comorbid condition in the sufferer. Some of the COPD comorbid that are often encountered include cardiovascular disease, metabolic syndrome, osteoporosis,lung cancer and muscle dysfunction.2Natriuretic peptide is a biomarker that is widely used to diagnose heart failure.N-Terminal pro Brain Natriuretic Peptide (NT-pro BNP), which is one type of natriuretic peptide, is apolypeptide produced by the ventricular myocardium due to stress on the heart wall. All of the complications to the heart caused by COPD as mentioned above will change the function and anatomical shape of the heart. Echocardiography is a non-invasive examination procedure that can be used to evaluate changes in the heart, both functionally and anatomically. Apart from being safer and more comfortable for thepatient, this examination has good sensitivity and specificity, so that this examination can be used in COPD patients both for screening, diagnosis and evaluation of cardiovascular complications. From several studies it was found that serum NT-proBNP concentrations were associated with an increase in end-diastolic pressure which was strongly associated with shortness of breath in heart failure and correlated with the prognosis of left ventricular dysfunction. This study wanted to assess the relationship between the abnormality of NT Pro BNP levels and echocardiographic features ofRV dysfunction with the severity of COPD which indicates changes in the structure and function of the heart.